Chemical Hay 28543 productos.

• Nuevo

  PROTAC IRAK4 degrader-7 

  PROTAC IRAK4 degrader-7 (Compound I-417) is a potentially first-in-class, orally active PROTAC IRAK4 degrader with antitumor activity for studies related to hidradenitis suppurativa (HS) and atopic dermatitis (AD).

  Más

  Añadir a Mis productos destacados
• Nuevo

  ARP-100 

  ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM).

  Más

  Añadir a Mis productos destacados
• Nuevo

  ARP-100 

  ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM).

  Más

  Añadir a Mis productos destacados
• Nuevo

  CDK-IN-2

  CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of

  Más

  Añadir a Mis productos destacados
• Nuevo

  CDK12-IN-2 

  CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM). CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12.

  Más

  Añadir a Mis productos destacados
• Nuevo

  3-Octanol

  3-Octanol is an octane fatty alcohol substituted with a hydroxyl group at the 3-position and can be used as a reducing agent.

  Más

  Añadir a Mis productos destacados
• Nuevo

  Myrcene

  Myrcene is a monoterpene compound found in many plants that inhibits both MAP kinase and NF-κB pathways, thereby suppressing colonic inflammation.

  Más

  Añadir a Mis productos destacados
• Nuevo

  Sacituzumab govitecan

  Sacituzumab govitecan is an antibody-drug concatenation (ADC) containing a humanized anti-trophoblast cell surface antigen 2 (TROP-2) antibody as well as the topoisomerase I inhibitor SN-38。It delivers high concentrations of SN-38 to tumors and can be used in studies related to triple-negative breast cancer.

  Más

  Añadir a Mis productos destacados
• Nuevo

  Lotilaner

  Lotilaner is a first-in-class, highly selective inhibitor of gamma-aminobutyric acid (GABA) gated chloride channels (GABACls) against mites. It has antiparasitic activity with an IC50 value of 23.84 nM against the Drosophila GABA receptor and can be used in studies related to helminth mite blepharitis.

  Más

  Añadir a Mis productos destacados
• Nuevo

  Trigriluzole

  Trigriluzole is an excitatory amino acid transporter protein 2 (EAAT2) modulator that increases the uptake of glutamate at neuronal synapses by increasing the expression and enhancing the function of EAAT in glial cells, thereby decreasing glutamate levels in neuronal synapses. It can be used in studies related to spinocerebellar ataxia (SCA) and anxiety...

  Más

  Añadir a Mis productos destacados
• Nuevo

  4-Methylumbelliferyl oleate

  4-Methylumbelliferyl oleate is a fluorescent substrate for acidic and alkaline lipases. It is cleaved by lipases and releases 4-Methylumbelliferyl (Ex/Em=320/450 nm).

  Más

  Añadir a Mis productos destacados
• Nuevo

  Polyethylenimine (MW 1200)

  Polyethylenimine is a surfactant that acts as a polyelectrolyte multilayer on a charged surface, providing that surface with a biocompatible coat.

  Más

  Añadir a Mis productos destacados