BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities.
Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities.
Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research.
Cadambine is a potent inhibitor of DNA Topoisomerase IB of Leishmania donovani (LdTOP1LS), isolated from Anthocephalus cadamba.
Vitamin K2 (Menaquinone-4) is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
Entadamide A is a natural product found in Entada rheedei and Entada gigas. Entadamide A inhibited the 5-lipoxygenase activity of RBL-1 cells at 10(-4) g/ml.
Entadamide A is a natural product found in Entada rheedei and Entada gigas. Entadamide A inhibited the 5-lipoxygenase activity of RBL-1 cells at 10(-4) g/ml.
Maduramicin, which could be isolated from the actinomycete Actinomadura rubra, is an antiprotozoal agent used in veterinary medicine to prevent coccidiosis.