Kudinoside D is a main natural component of triterpenoid saponin derived from Ilex kudingcha. Kudinoside D suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes.
AZD4573 is a potent and highly selective CDK9 inhibitor (IC50 values less than 4 nM) can be used to study hematologic malignancies.
NVP-2 is an effective and selective ATP competitive cyclin-dependent kinase 9 (CDK9) probe that inhibits CDK9/CycT activity.IC50 The value is 0.514 nM. NVP-2 has inhibitory effects on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases, which IC50 The values are 0.584 μM, 0.706 μM, and 0.605 μM, respectively. NVP-2 induces apoptosis.
MRTX-1719 is a potent, first-of-its-kind, selective PRMT5/MTA complex inhibitor against PRMT5/MTA MTAPDEL SDMA CELL LINES IC50 The value is
MRTX-1719 is a potent, first-of-its-kind, selective PRMT5/MTA complex inhibitor against PRMT5/MTA MTAPDEL SDMA CELL LINES IC50 The value is
MRTX9768 is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor.
MRTX9768 is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor.
WNK463 is an oral WNK kinase inhibitor for WNK1, WNK2, WNK3, and WNK4 IC50 The values are 5 nM, 1 nM, 6 nM, and 9 nM, respectively.