N6F11 is a novel ferroptosis inducer that selectively triggers the ubiquitination degradation of GPX4 by binding to the specific structural domain of TRIM25, a ubiquitinated E3 ligase, which is expressed in tumor cells, leading to ferroptosis in cancer cells.
Fuzapladib is a leukocyte adhesion molecule and an orally active inhibitor of leukocyte function-associated antigen type 1 (LFA-1) activation.Fuzapladib is also a phospholipase A2 (PLA2) inhibitor, which exerts anti-inflammatory activity by inhibiting the migration of leukocytes to sites of inflammation.
Fuzapladib is a leukocyte adhesion molecule and an orally active inhibitor of leukocyte function-associated antigen type 1 (LFA-1) activation.Fuzapladib is also a phospholipase A2 (PLA2) inhibitor, which exerts anti-inflammatory activity by inhibiting the migration of leukocytes to sites of inflammation.
α-Conotoxin AuIB TFA is a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist that blocks α3β4 nAChRs expressed in African clawed toad oocytes with an IC50 of 0.75 μM.
α-Conotoxin MII TFA, a natural product isolated from the sea snail Conus magus, can effectively inhibit the α3β2 subunit of the nAChR receptor, with an IC50 value of 0.5 nM. In addition, α-Conotoxin MII TFA can effectively inhibit the activity of β3-containing neuro-nicotinic receptor.
Proteasome-activating peptide 1 is a peptide, which increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture.
DL-α-(Difluoromethyl)arginine is an potent, enzyme-activated and irreversible arginine decarboxylases inhibitor.
Lipoprotein lipase, Pseudomonas sp is a multifunctional enzyme from adipose tissue, cardiac and skeletal muscle, pancreatic islets, and macrophages.Lipoprotein lipase promotes normal lipoprotein metabolism, tissue-specific substrate delivery and utilization, and catalyzes the rate-limiting step of lipids in the circulation.
Lipoprotein lipase, Pseudomonas sp is a multifunctional enzyme from adipose tissue, cardiac and skeletal muscle, pancreatic islets, and macrophages.Lipoprotein lipase promotes normal lipoprotein metabolism, tissue-specific substrate delivery and utilization, and catalyzes the rate-limiting step of lipids in the circulation.
IDE397 (GSK-4362676) is a potent, potential "first-in-class" inhibitor of methionine adenosyltransferase 2A (MAT2A). IDE397 (GSK-4362676) exhibits anti-tumor activity in MTAP-deleted PDX models.
IDE397 (GSK-4362676) is a potent, potential "first-in-class" inhibitor of methionine adenosyltransferase 2A (MAT2A). IDE397 (GSK-4362676) exhibits anti-tumor activity in MTAP-deleted PDX models.
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity. Gly-Pro-AMC hydrobromide have fluorescence properties, with the fluorescence detection conditions: excitation wavelength 350 nm, fluorescence emission spectrum detection 450 nm.