Dihydrocucurbitacin B is a triterpenoid in the tariae root that inhibits the activation of T-cell nuclear factors, induces arrest in the G0 phase of the cell cycle, and inhibits delayed hypersensitivity reactions.
Levomenol ((-)-α -bisabolol) isa monocyclic sesquiterpenoid alcohol with antioxidant, anti-inflammatory and anti-apoptotic effects. Levomenol also has neuroprotective effects, preventing neuronal damage and memory deficits by reducing pro-inflammatory markers of permanent focal cerebral ischemia induction in mice. Levomenol reduces nociceptive behavior...
Pogostone is isolated from mint and has antibacterial and anticancer activities. Pogostone inhibited gram-negative bacteria and Gram-positive bacteria, and also showed inhibitory effect on Bacillus sclericae, with MIC value of 0.098 µg/mL. Pogostone can induce apoptosis and autophagy.
Desmopressin is a synthetic octapeptide that is an analogue of the human hormone arginine vasopressin and has antidiuretic and procoagulant effects.
Desmopressin is a synthetic octapeptide that is an analogue of the human hormone arginine vasopressin and has antidiuretic and procoagulant effects.
Trimethylamine n-oxide is a microbiome dependent metabolite of dietary choline and other Trimethylamine nutrients. It belongs to the amine oxide class. Trimethylamine n-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine n-oxide also accelerates fibroblast differentiation and induces cardiac fibrosis by activating the...
Trimethylamine n-oxide is a microbiome dependent metabolite of dietary choline and other Trimethylamine nutrients. It belongs to the amine oxide class. Trimethylamine n-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine n-oxide also accelerates fibroblast differentiation and induces cardiac fibrosis by activating the...
L-palmitoyl carnitine is a long-chain acylcarnitine and fatty acid metabolite that accumulates in the sarcoid during ischemia and disrupts the membrane lipid environment. L-palmitoylcarnitine inhibits KATP channel activity by interacting with Kir6.2 without affecting single channel conductance.
L-palmitoyl carnitine is a long-chain acylcarnitine and fatty acid metabolite that accumulates in the sarcoid during ischemia and disrupts the membrane lipid environment. L-palmitoylcarnitine inhibits KATP channel activity by interacting with Kir6.2 without affecting single channel conductance.
DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs).
DBCO-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb/CDK9 inhibitor. Atuveciclib (BAY-1143572) inhibits CDK9/CycT1 with an IC50 of 13 nM.