DIMBOA is a powerful antibiotic present in maize, wheat, and related grasses, possess growth inhibitory properties against many strains of studied bacteria and fungi, such as Staphylococcus aureus, Escherichia coli as well as against Saccharomyces cerevisiae. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the...
Alternariol is a mycotoxin produced by Alternaria species. Alternariol inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes.
Methoxyamine is an orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis.
Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate.
Alternariol is a mycotoxin produced by Alternaria species. Alternariol inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes.
Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and cisplatin-induced cochlear injury.
RGX-104 hydrochloride is a small-molecule LXR (liver X receptor) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
L-Quebrachitol is a natural product isolated from a variety of plants that promotes osteoblast production by upregulating BMP-2, runt-associated transcription factor (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathways.
L-Quebrachitol is a natural product isolated from a variety of plants that promotes osteoblast production by upregulating BMP-2, runt-associated transcription factor (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathways.
Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel. Dooku1 inhibits 2 μM Yoda1-induced Ca2+Incoming, IC50 values in HEK 293 cells and HUVECs are 1.3 μM and 1.5 μM, respectively.
Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel. Dooku1 inhibits 2 μM Yoda1-induced Ca2+Incoming, IC50 values in HEK 293 cells and HUVECs are 1.3 μM and 1.5 μM, respectively.