Interleukin-6 Receptor Alpha belongs to the type I cytokine receptor family. It binds specifically to IL-6 and depends on gp130 to transmit signals. Measured in a cell proliferation assay using M1 cells in the presence of 10.0 ng/ mL human IL-6, the ED50 is < 0.2 μg/mL.
Recombinant human CYP3A4 is an important member of cytochrome P45 enzyme superfamily, with 33 alleles. Systemic inflammation is associated with inhibition of CYP3A4 activity.
Leukemia Inhibitory Factor (LIF) is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and...
Recombined human IL-15 MAX Protein sequence: DNA encoding human IL-10 (P40933) Bioactivity: Cell proliferation was measured with MO7e human megakaryocytic leukemia cells with an ED50 of 7-28 ng/mL
Recombined human IL-15 MAX Protein sequence: DNA encoding human IL-10 (P40933) Bioactivity: Cell proliferation was measured with MO7e human megakaryocytic leukemia cells with an ED50 of 7-28 ng/mL
Bioactivity: CD16 is FcγR ⅲ, a glycoprotein with a molecular weight of 50-70kD, a member of Ig superfamily, known to be involved in antigen-dependent cytotoxicity (ADCC). The most significant feature of CD16 is that the cleavage triggered by membrane receptors is performed by NK cells.
Biological activity: HER2, also known as ErbB2, is a member of the human epidermal growth factor receptor family and plays an important role in signal transduction.
Biological activity: PD-1 is mainly expressed in activated T cells and B cells, and its function is to inhibit cell activation, which is a normal self-stabilizing mechanism of the immune system. Because excessive T/B cell activation can cause autoimmune diseases, PD-1 is a talisman of our body.
Recombinant Human CD19 Protein (HEK293) Protein sequence: THE DNA sequence encoding human CD19 (UniProtKB/ Swiss-PROt: P15391.6) was expressed with His tag at the C-terminal. Bioactivity: Immobilized CD19 monoclonal antibody at 5μg/mL (100 μL/ well) can bind CD19 protein in a linear range of 5-100ng/mL
CD20 is a specific marker molecule on the surface of B lymphocytes. It is expressed on more than 95% of normal or malignant B lymphocytes and is not expressed in hematopoietic stem cells, progenitor cells, and other normal tissues.
Biological activity: CD137(also known as 4-1BB) is an inducible cell surface receptor, a member of the tumornecrosis factor receptor (TNFR) superfamily.
Recombinant Human 4-1BB Protein (HEK293) Protein sequence: DNA sequence encoding human 4-1BB (UniProtKB/ Swiss-PROt: Q07011.1) expressed with His tag at the C-terminal Bioactivity: 4-1BB, also known as CD137, is a member of the tumor necrosis factor receptor superfamily 9 (TNFRSF9) induced by lymphocyte activation (ILA), and is a costimulatory molecule...