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LY294002
S-S1105-10mg
Producto nuevo
LY294002
Al comprar este producto puede obtener hasta 15 puntos de fidelidad. Su cesta totalizará 15 puntos de fidelidad que se puede(n) transformar en un cupón de descuento de 3.00EUR.
Ficha de datos
| Size | 10mg |
| Target | Moleculas Pequeñas |
| CAS Number | 154447-36-6 |
| Small Target | PI3K |
| Pathway | PI3K/Akt/mTOR |
| Smiles | O=C1C=C(OC2=C(C=CC=C12)C3=CC=CC=C3)N4CCOCC4 |
Más información
LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/βwith IC50of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcsinhibitor and activates autophagyand apoptosis.