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Zotatifin
S-S8994-1mg
Producto nuevo
Zotatifin
Al comprar este producto puede obtener hasta 164 puntos de fidelidad. Su cesta totalizará 164 puntos de fidelidad que se puede(n) transformar en un cupón de descuento de 32.80EUR.
Ficha de datos
| Size | 1mg |
| CAS Number | 2098191-53-6 |
Más información
Zotatifin (eFT226) is a highly effective and sequence-selective inhibitor of the RNA helicase eIF4A. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs, with an IC50 of 2 nM, and disrupts the assembly of the eIF4F initiation complex. By enhancing the interaction between eIF4A and polypurine RNA sequence or structural motifs, zotatifin converts eIF4A into a sequence-specific translation repressor, thereby regulating the translation of certain target genes. It also exhibits anti-tumor activity.