Cucurbitacin IIb is the active ingredient in chorioides, which induces apoptosis and has anti-inflammatory activity. Cuc
ONO-AE3-208 is an orally active prostaglandin E2 receptor 4 (EP4)-selective antagonist (Ki in nM = 1.
Bimiralisib (PQR309) is a potent, brain-penetrant, orally bioavailable inhibitor of PI3K and mTOR, with potential antineoplastic activity.
YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity. YUM70 induces endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer.
2-Hydroxymethyl-5-hydroxypyridine is isolated from the the matured, ripened and dried seeds of S. lychnophora.
DSPE-PEG-2K-Amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE, used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.
Obeticholic Acid (INT-747) is a potent, orally active, selective farnesoid X receptor (FXR) agonist with an EC50 of 99 nM.May be used in studies related to non-alcoholic steatohepatitis (NASH).
Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.
Oxeladin citrate is a cough suppressant, is a highly potent and effective drug used to treat all types of cough of various etiologies.
[8]-Shogaol, an irritant phenolic compound from ginger, has antiplatelet activity (IC50=5 μM) and inhibition of COX-2 (IC50=17.5 μM). [8]-Shogaol induces apoptosis of human leukemia cells.
Serotonin is a monoamine neurotransmitter and endogenous 5-HT receptor agonist in CNS. Serotonin is also an inhibitor of catechin-o-methyltransferase (COMT) with a Ki value of 44 μM. Serotonin is also a natural product of animals.