QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells.
Entacapone is an inhibitor of FTO demethylation with IC50 of 3.5 μM, Entacapone also inhibits catechol-O-methyltransferase (COMT) with IC50 of 151 nM.
Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs).
Edaravone is a radical scavenger and antioxidant which is able to protect against the effects of ischemia.
Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
EC5026 (BPN-19186) is a first-in-class, potent and orally active soluble inhibitor of Epoxide Hydrolase (sEH). EC5026 has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators.
Disufide crosslinks of cystines in proteins can be reduced to cysteine residues by TCEP (tris-(2-carboxyethyl)phosphine). Unlike DTT (dithiothreitol), TCEP does not contain thiols and therefore usually does not need to be removed prior to thiol modification.
CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines.
Lomitapide Mesylate is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia.