K-975 is a potent, selective and orally active TEAD inhibitor that strongly inhibits protein-protein interactions between YAP1/TAZ and TEAD.
Mirodenafil is a newly developed oral type 5 phosphodiesterase inhibitor. mirodenafil is a modulator of the glucocorticoid receptor (GR). mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating the expression of Dkk1. mirodenafil can be used to study erectile dysfunction (ED), Alzheimer's disease (AD) and systemic sclerosis (SSc)....
K-975 is a potent, selective and orally active TEAD inhibitor that strongly inhibits protein-protein interactions between YAP1/TAZ and TEAD.
Ompenaclid (RGX-202-01) is an orally active inhibitor of SLC6A8 transport protein. Ompenaclid (RGX-202-01) strongly inhibits creatine import in vitro and in vivo, decreases intracellular phosphocreatine and ATP levels, and induces apoptosis. Ompenaclid (RGX-202-01) has been used in oncology and Duchenne muscular dystrophy studies.
Ompenaclid (RGX-202-01) is an orally active inhibitor of SLC6A8 transport protein. Ompenaclid (RGX-202-01) strongly inhibits creatine import in vitro and in vivo, decreases intracellular phosphocreatine and ATP levels, and induces apoptosis. Ompenaclid (RGX-202-01) has been used in oncology and Duchenne muscular dystrophy studies.
Pamoic acid is a potent GPR35 agonist with EC50 at 79 nM. Pamoic acid has neuroprotective and anti-inflammatory properties.
Plitidepsin (Aplidine) is a potent anticancer compound targeting eEF1A2 (KD=80 nM). Plitidepsin has antiviral activity, and the IC90 of inhibiting SARS-CoV-2 is 0.88 nM. Plitidepsin is commonly used in multiple myeloma and advanced cancer research and has potential for COVID-19 research.
Menadiol (Dihydrovitamin K3), a menaquinol analogue, is an electron donor for reversed oxidative phosphorylation in submitochondrial particles.
Menadiol (Dihydrovitamin K3), a menaquinol analogue, is an electron donor for reversed oxidative phosphorylation in submitochondrial particles.
BPTF-IN-BZ1 is a BPTF (Bromodomain PHD Finger Transcription Factor) inhibitor, with a high potency (Kd = 6.3 nM).