Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome.
RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon....
5,6-Dichlorobenzimidazole riboside is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs. 5,6-Dichlorobenzimidazole riboside trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells.
5,6-Dichlorobenzimidazole riboside is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs. 5,6-Dichlorobenzimidazole riboside trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells.
dl-Carvone is a monoterpene ketone found in the essential oils of medicinal plants, and is also a plant antifungal, as well as an insecticide with anti-inflammatory activity.
1-Hexanol is a tertiary alcohol that also acts as a surfactant and uncouples mitochondrial respiration by a nonprotonic mechanism.
AOH1160 is a potent, first-in-class, orally active inhibitor of proliferating cell nuclear antigen (PCNA) that also interferes with DNA replication, blocks homologous recombination-mediated DNA repair, as well as causes cell cycle arrest and induces apoptosis, and can be used in oncology-related studies.
AOH1996 is an orally active small molecule PCNA inhibitor, which can be obtained by adding a methoxy group to the interstitial position of the benzene ring at the end of AOH1160, and enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II, as well as selectively kills cancer cells, which can be used in cancer-related...
AOH1160 is a potent, first-in-class, orally active inhibitor of proliferating cell nuclear antigen (PCNA) that also interferes with DNA replication, blocks homologous recombination-mediated DNA repair, as well as causes cell cycle arrest and induces apoptosis, and can be used in oncology-related studies.
AOH1160 is a potent, first-in-class, orally active inhibitor of proliferating cell nuclear antigen (PCNA) that also interferes with DNA replication, blocks homologous recombination-mediated DNA repair, as well as causes cell cycle arrest and induces apoptosis, and can be used in oncology-related studies.
Polyethylenimine Linear (PEI) is a broadly applicable cationic polymer transfection reagent with a molecular weight of 40,000 that forms a complex with nucleic acids and allows the complex to enter mammalian cells.