TC11 is a phenylphthalimide derivative and an activator of caspase-9 and CDK1, as well as a degrader of MCL1.TC11 is structurally related to immunomodulatory active molecules. During prolonged mitotic blockade, TC11 induces MCL1 degradation and leads to apoptotic death.
Tuvusertib is a selective and orally active ATR inhibitor that kills tumor cells by preventing the repair of damaged DNA with a Ki value below 1 μΜ.
Tuvusertib is a selective and orally active ATR inhibitor that kills tumor cells by preventing the repair of damaged DNA with a Ki value below 1 μΜ.
Sulfogaiacol is a antitussive agent. Sulfogaiacol is used for acute respiratory tract infections, cough and other conditions.
Sulfogaiacol is a antitussive agent. Sulfogaiacol is used for acute respiratory tract infections, cough and other conditions.
Qingdainone is a natural product that can be obtained from Qingdai. Qingdainone has the potential to study cancer and inflammation
Bis-PEG2-acid (COOH-PEG1-COOH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
PT-179 is an orthogonal Thalidomide (M2225) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein.
PT-179 is an orthogonal Thalidomide (M2225) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein.
WM-8014, also known as MOZ-IN-3, is a highly potent inhibitor of MOZ with an IC50 of 55 nM.
WM-8014, also known as MOZ-IN-3, is a highly potent inhibitor of MOZ with an IC50 of 55 nM.
Mobocertinib (TAK-788) is an investigational TKI with potent, selective preclinical activity against activating EGFR and HER2 mutations, including exon 20 insertions.