N6F11 is a novel ferroptosis inducer that selectively triggers the ubiquitination degradation of GPX4 by binding to the specific structural domain of TRIM25, a ubiquitinated E3 ligase, which is expressed in tumor cells, leading to ferroptosis in cancer cells.
PF-07220060 is a potent CDK4/CDK6 inhibitor with Ki values of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3.
PF-07220060 is a potent CDK4/CDK6 inhibitor with Ki values of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3.
α-Conotoxin MII TFA, a natural product isolated from the sea snail Conus magus, can effectively inhibit the α3β2 subunit of the nAChR receptor, with an IC50 value of 0.5 nM. In addition, α-Conotoxin MII TFA can effectively inhibit the activity of β3-containing neuro-nicotinic receptor.
α-Conotoxin PIA TFA is a nicotinic acetylcholine receptor (nAChR) antagonist that targets the nAChR, which contains both the α6 and α3 subunits. α-Conotoxin PIA TFA can be used in studies related to Parkinson's disease and schizophrenia.
Palmitoyl pentapeptide 4 (Matrixyl; Palmitoyl pentapeptide 3; Matrixyl (Palmitoyl Pentapeptide) is a bioactive peptide with anti-ageing effect and has been reported used as a cosmetic ingredient.
Palmitoyl pentapeptide 4 (Matrixyl; Palmitoyl pentapeptide 3; Matrixyl (Palmitoyl Pentapeptide) is a bioactive peptide with anti-ageing effect and has been reported used as a cosmetic ingredient.
IDH1 Inhibitor 8 is an isocitrate dehydrogenase 1 (IDH1) inhibitor that can be used in cancer-related studies.
Tuvusertib is a selective and orally active ATR inhibitor that kills tumor cells by preventing the repair of damaged DNA with a Ki value below 1 μΜ.
IDH1 Inhibitor 8 is an isocitrate dehydrogenase 1 (IDH1) inhibitor that can be used in cancer-related studies.
IDH1 Inhibitor 8 is an isocitrate dehydrogenase 1 (IDH1) inhibitor that can be used in cancer-related studies.
APE1-IN-1 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC50 value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate to cancer cells.