Erenumab is a first-in-class fully human monoclonal CGRP antibody. Erenumab inhibits the calcitonin gene–related peptide (CGRP) receptor. Erenumab can be used for the research of episodic migraine.
Tezepelumab (AMG 157) is a first-in-class human monoclonal antibody (IgG2λ) that binds specifically to TSLP, blocking it from interacting with its heterodimeric receptor. Tezepelumab can be used for the research of severe, uncontrolled asthma.
β-Naphthoflavone is an aryl hydrocarbon receptor (AhR) agonist, used as a positive control for the induction of AhR transcriptional activity. β-Naphthoflavone inhibits hydrogen peroxide-induced apoptosis.
[Ala11,D-Leu15]-Orexin B (human) acetate is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B (human) acetate shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (EC50=52 nM).
Tembotrione is a compound that may reduce the productivity of carrots. Tembotrione has the activity of reducing carrot stem mass.
Tembotrione is a compound that may reduce the productivity of carrots. Tembotrione has the activity of reducing carrot stem mass.
Gepotidacin (GSK2140944) is a novel, potentially first-in-class, orally active triazaacenaphthylene antibiotic and type II topoisomerase (Topo II) inhibitor.Gepotidacin can selectively inhibit bacterial DNA replication by acting on DNA gyrase (GyrA) and topoisomerase IV (ParC).
Gepotidacin (GSK2140944) is a novel, potentially first-in-class, orally active triazaacenaphthylene antibiotic and type II topoisomerase (Topo II) inhibitor.Gepotidacin can selectively inhibit bacterial DNA replication by acting on DNA gyrase (GyrA) and topoisomerase IV (ParC).
GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1 can be used for HCV infection research.
GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1 can be used for HCV infection research.
(R)-ZINC-3573 is a selective Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist with an EC50 value of 740 nM. (R)-ZINC-3573 can be used as a MRGPRX2 probe for the research of pain and itch.