Protein Construction:OSM (Ala24-Arg206) Oncostatin M (OSM) is a multifunctional cytokine belonging to the interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia suppressor (LIF), ciliary nerve promoter, cardiac trophic factor-1 and novel nerve promoter factor-1. Protein structure: OSM (ALA24-ARG206), Accession # : P53347.
Noggin protein, Mouse (CHO), is a bone morphogenetic protein (BMP) antagonist.
Tislelizumab, a monoclonal antibody with high binding affinity to the PD-1 receptor, minimizes Fcγ receptor binding on macrophages, thereby abrogating antibody-dependent phagocytosis, a mechanism of T cell clearance and potential resistance to anti-PD-1 therapy. Tislelizumab can be used for the research of advanced squamous non-small-cell lung cancer.
Human Interleukin-33 (IL-33) is a proinflammatory cytokine that belongs to the IL-1 family. IL-33 plays a role in autoimmune disease. IL-33’s interaction with ST2 can drive allergic pathology and IL-33 has been reported to play a role in the development of rheumatoid arthritis and systemic lupus erythematosus.
Interferon inducible protein 10 (IP-10)/CXCL10 was originally thought to be an IFN-γ- inducible gene in monocytes, fibroblasts, and endothelial cells. LPS, IL-1β, TNF-α, IL-12 and virus can also induce the expression of IP-10 mRNA. Protein structure: CXCL10 (ILE22-PRO98), Accession # :Q548V9.
IL-34 is a cytokine that promotes monocyte and macrophage differentiation and viability via colony-stimulating factor-1 receptor (CSF1R). The ED50 is 50-200 ng/mL as measured in a cell proliferation assay using M-NFS-60 mouse bone marrow cells.
Interleukin-2 (IL-2) is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.
Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.
Recombinant human Neuregulin-1 Beta is produced by the escherichia coli expression system and the target gene encoding Ser2-Lys246 is expressed. Accession # : AAA58639.1.
The EC50 value of human MCP-1/CCL2 on Ca2+ mobilization assay in CHO-K1/Gα15/hCCR2 cells (human Gα15 and human CCR2 stably expressed in CHO-K1 cells) is less than 1.0 μg/ml. Accession # : P13500.
Marstacimab (PF-06741086) is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody. Marstacimab can be used for the research of hemophilia.
Recombinant rat S100 calcium-binding protein A8 is produced by the E. coli expression system and the target gene encoding Met1-Glu89 has a 6His tag at the C-terminus. Protein ID:P50115.