Durvalumab (MEDI 4736) is an humanized anti-PD-L1 monoclonal antibody, it completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04 nM, respectively. Durvalumab was inactive against the mPD-L1.
PLA2G2A, is a peripheral membrane protein that belongs to the phospholipase A2 family. PLA2G2A plays a role in anti-bacterial defense, inflammation and eicosanoid generation, in clearance of apoptotic cells, and in the Wnt signaling pathway.
Recombinant Mouse IL-6 Protein is a multifunctional cytokine that regulates various immune and inflammatory responses.
Sarilumab is a human recombinant IgG1 antibody that binds to both forms of interleukin 6 receptors (IL-6R), thus inhibiting the IL-6-mediated signaling.
Interleukin-8 (IL-8), also known as CXCL8, GCP-1 and NAP-1, is one of the first discovered chemokines and belongs to the CXCL family, in which the first two conserved cysteines are separated by one residue. Protein Construction: IL-8 (Ala23-Ser99). Accession # P10145.
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R...
Recombinant human hepatocyte growth factor is produced by the mammalian expression system and the target gene encodes GLN32-Ser728 to express the 6His marker at the C-terminal.
BMP-4 is involved in the development and maintenance of bone and cartilage. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells.
Recombinant human macrophage migration inhibitor (rhMIF) is a single nonglycosylated polypeptide chain of 115 amino acids produced in Escherichia coli. Accession # P14174.
PDGF has three subforms: PDGF-AA, PDGF-BB, PDGF-AB. It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. Protein structure: PDGF-BB (Ser82-Thr190)
Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that binds to the Kunitz-type protease inhibitor (KPI) 2 structural domain of TFPI, thereby blocking the interaction of this structural domain with the FXa active site. Concizumab can be used in the study of haemophilia.
IP-10 /CXCL10, also known as CXCL10, was originally thought to be an IFN-γ- induced gene in monocytes, fibroblasts, and endothelial cells. LPS, IL-1β, TNF-α, IL-12 and virus can also induce the expression of IP-10 mRNA. Expressed with an N-terminal Met. CXCL10 (VAL22-PRO98), Accession # :P02778.