BMPR1A/ALK-3/CD292 protein is expressed in the epithelium during branching morphogenesis. It is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. BMPR1A/ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity...
DSP proteins are major components of desmosomes and are critical for the structural integrity of various tissues. In cardiomyocytes, DSP regulates profibrotic gene expression through MAPK14/p38 MAPK activation and increased TGFB1 protein.
DSP proteins are major components of desmosomes and are critical for the structural integrity of various tissues. In cardiomyocytes, DSP regulates profibrotic gene expression through MAPK14/p38 MAPK activation and increased TGFB1 protein.
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R...
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R...
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R...
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R...
Cadherin-17 is a single-pass type I membrane protein that belongs to the cadherin superfamily. Cadherin-17 is expressed in the gastrointestinal tract and pancreatic duct. Cadherin-17 plays a role in the morphological organization of liver and intestine and involved in intestinal peptide transport.
Cadherin-16 (CDH16) is a single-pass type I membrane protein which contains six cadherin domains. CDH16 is exclusively expressed in kidney, where the protein functions as the principal mediator of homotypic cellular recognition. It plays a role in the morphogenic direction of tissue development.
Interferon Alpha/Beta Receptor 1 (IFNAR1) interacts very weakly or not at all with type 1 interferons and does not stably interact with IFN-α/β R2. Ligands associate with IFN-α/β R2, and this complex subsequently forms a stable ternary assembly with IFN-α/β R1. IFN-α/β R1 also associates with IFN-γ R2 even in the absence of IFN-γ stimulation.
Interferon Alpha/Beta Receptor 1 (IFNAR1) interacts very weakly or not at all with type 1 interferons and does not stably interact with IFN-α/β R2. Ligands associate with IFN-α/β R2, and this complex subsequently forms a stable ternary assembly with IFN-α/β R1. IFN-α/β R1 also associates with IFN-γ R2 even in the absence of IFN-γ stimulation.
Prostaglandin-D2 Synthase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions, such as sedation, REM sleep and PGE2-induced allodynia,...