dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC) which exhibits significant and selective degradation of BRD4 BD1 but is inactive on BRD4 BD2.
MSA-2 is an orally available non-nucleotide STING agonist with antitumor activity. MSA-2 shows EC50 values of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively.
MSA-2 is an orally available non-nucleotide STING agonist with antitumor activity. MSA-2 shows EC50 values of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively.
Tucidinostat (HBI-8000; Chidamide; CS-055) HCl is a benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10 with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively.
Tucidinostat (HBI-8000; Chidamide; CS-055) HCl is a benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10 with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively.
Probenecid sodium is a sodium salt of Probenecid that is soluble in water. Probenecid (Benemid) is an organic anionic transport competitive inhibitor, as well as an agonist of transient receptor potential vanillin receptor subfamily 2(TRPV2) and an inhibitor of human bitter taste receptor TAS2R16.
Tucidinostat (HBI-8000; Chidamide; CS-055) HCl is a benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10 with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively.
GSK2193874 is a first-in-class orally bioavailable potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist with IC50 values of 2, 5, and 40 nM. GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor that demonstrated ability to improve pulmonary functions in a number of heart failure models.
GSK2193874 is a first-in-class orally bioavailable potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist with IC50 values of 2, 5, and 40 nM. GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor that demonstrated ability to improve pulmonary functions in a number of heart failure models.
Indotecan (LMP-400) is a potent topoisomerase 1 (Top1) inhibitor. Indotecan (LMP-400) for P388, HCT116, MCF-7 cell linesIC50 The values are 300, 1200, 560 nM, respectively.
Indotecan (LMP-400) is a potent topoisomerase 1 (Top1) inhibitor. Indotecan (LMP-400) for P388, HCT116, MCF-7 cell linesIC50 The values are 300, 1200, 560 nM, respectively.
Exenatide Acetate (Exendin-4) is a first-in-class glucagon-like peptide 1 (GLP-1) receptor agonist consisting of 39 amino acids.